An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an α/β-hydrolase fold

被引：70

作者：

Andexer, Jennifer

von Langermann, Jan

Mell, Annett

Bocola, Marco

Kragl, Udo

Eggert, Thorsten

Pohl, Martina

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] Evocatal GmbH, D-40225 Dusseldorf, Germany

[3] Univ Dusseldorf, Inst Mol Enzyme Technol, D-52426 Julich, Germany

[4] Univ Regensburg, Dept Phys Biochem 2, D-93053 Regensburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 45期

关键词：

cyanohydrins; enzyme catalysis; genetic engineering; hydroxynitrile lyases; oxynitrilases;

D O I：

10.1002/anie.200701455

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Folding and selectivity: The noncyanogenic plant Arabidopsis thaliana contains a new hydroxynitrile lyase, which was cloned and characterized. This enzyme is readily available form a recombinant source, has a broad range of substrates, and enantioselectively transforms aliphatic and aromatic aldehydes as well as ketones into the corresponding R-cyanohydrins. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8679 / 8681

页数：3

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