Chromatin fiber structure: Where is the problem now?

被引：84

作者：

van Holde, Ken ^{[1
]}

Zlatanova, Jordanka ^{[2
]}

机构：

[1] Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USA

[2] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 05期

基金：

美国国家科学基金会;

关键词：

30 nm chromatin fiber; solenoid; two-start helix; chromatin dynamics; chromatin compaction;

D O I：

10.1016/j.semcdb.2007.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The structure of the "30 nm chromatin fiber", as observed in vitro, has been a matter of controversy for 30 years. Recent studies with new and more powerful techniques give some promise for resolution. However, this will not necessarily inform us as to the in vivo structure, which may be both heteromorphic and dynamic. In this chapter, we briefly review the older conjectures and some more recent studies of special interest. We attempt to point out the remaining contradictions and hopeful lines of future research. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：651 / 658

页数：8

共 51 条

[1] Role of histone tails in chromatin folding revealed by a mesoscopic oligonucleosome model [J].

Arya, Gaurav ;

Schlick, Tamar .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (44) :16236-16241

[2] Flexible histone tails in a new mesoscopic oligonucleosome model [J].

Arya, Gaurav ;

Zhang, Qing ;

Schlick, Tamar .

BIOPHYSICAL JOURNAL, 2006, 91 (01) :133-150

[3] Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin [J].

Bednar, J ;

Horowitz, RA ;

Grigoryev, SA ;

Carruthers, LM ;

Hansen, JC ;

Koster, AJ ;

Woodcock, CL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14173-14178

[4] Visualization and analysis of chromatin by scanning force microscopy [J].

Bustamante, C ;

Zuccheri, G ;

Leuba, SH ;

Yang, GL ;

Samori, B .

METHODS, 1997, 12 (01) :73-83

[5] A DEFINED STRUCTURE OF THE 30-NM CHROMATIN FIBER WHICH ACCOMMODATES DIFFERENT NUCLEOSOMAL REPEAT LENGTHS [J].

BUTLER, PJG .

EMBO JOURNAL, 1984, 3 (11) :2599-2604

[6] High concentration of DNA in condensed chromatin [J].

Daban, JR .

BIOCHEMISTRY AND CELL BIOLOGY, 2003, 81 (03) :91-99

[7] Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 Å resolution [J].

Davey, CA ;

Sargent, DF ;

Luger, K ;

Maeder, AW ;

Richmond, TJ .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 319 (05) :1097-1113

[8] Nucleosome arrays reveal the two-start organization of the chromatin fiber [J].

Dorigo, B ;

Schalch, T ;

Kulangara, A ;

Duda, S ;

Schroeder, RR ;

Richmond, TJ .

SCIENCE, 2004, 306 (5701) :1571-1573

[9] SOLENOIDAL MODEL FOR SUPERSTRUCTURE IN CHROMATIN [J].

FINCH, JT ;

KLUG, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :1897-1901

[10] CHROMATIN STRUCTURE OF SCHIZOSACCHAROMYCES-POMBE - A NUCLEOSOME REPEAT LENGTH THAT IS SHORTER THAN THE CHROMATOSOMAL DNA LENGTH [J].

GODDE, JS ;

WIDOM, J .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 226 (04) :1009-1025

← 1 2 3 4 5 6 →