PX domains: attracted by phosphoinositides

被引:64
作者
Simonsen, A [1 ]
Stenmark, H [1 ]
机构
[1] Norwegian Radium Hosp, Dept Biochem, N-0310 Oslo, Norway
关键词
D O I
10.1038/35087112
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive, has been demonstrated to bind phosphoinositides. The interactions of PX-domain-containing proteins with specific phosphoinositides are critical for cellular activities such as microbial killing and membrane trafficking.
引用
收藏
页码:E179 / E182
页数:4
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