Biocompatibility of Acellular Nerves of Different Mammalian Species for Nerve Tissue Engineering

被引：11

作者：

Jia, Hua ^{[1
]}

Wang, Ying ^{[1
]}

Tong, Xiao-Jie ^{[1
]}

Liu, Gui-Bo ^{[1
]}

Li, Qi ^{[2
]}

Zhang, Li-Xin ^{[3
]}

Sun, Xiao-Hong ^{[4
]}

机构：

[1] China Med Univ, Coll Basic Med Sci, Dept Anat, Shenyang 110001, Peoples R China

[2] Shenyang Med Coll, Affiliated Feng Tian Hosp, Dept Hand Surg, Shenyang, Peoples R China

[3] China Med Univ, Affiliated Sheng Jing Hosp, Dept Rehabil Med, Shenyang, Peoples R China

[4] China Med Univ, Affiliated Hosp 4, Dept Neurol, Shenyang, Peoples R China

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2011年 / 39卷 / 06期

基金：

高等学校博士学科点专项科研基金;

关键词：

Tissue engineering; biocompatibility; acellular nerve xenograft; bone marrow stromal cells; MARROW STROMAL CELLS; REGENERATION; TRANSPLANTATION; GROWTH; REPAIR; EXPRESSION; ALIGNMENT; COLLAGEN; NEURONS; GRAFTS;

D O I：

10.3109/10731199.2011.618133

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To explore the biocompatibility of acellular nerves of different mammalian species, for the acellular nerves derived from rats and rabbits, the morphology, immunocompatibility, and cytocompatibility with bone marrow stromal cells (BMSCs) were evaluated. The results indicated that the tridimensional architecture and main proteins of endoneurial tubes in both biomaterials were well retained. The nerve scaffolds did not show immunogenicity or cytotoxicity, but facilitated growth of BMSCs and secretion of neurotrophic factors in vitro. In conclusion, acellular nerves of different species possess favorable biocompatibility, and xenogenic acellular nerves combined with BMSCs have potential to replace allografts for peripheral nerve reconstruction.

引用

页码：366 / 375

页数：10

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