Investigation of restricted backbone conformations as an explanation for the exceptional thermal stabilities of duplexes involving LNA (locked nucleic acid): synthesis and evaluation of abasic LNA

被引：16

作者：

Kvaerno, L ^{[1
]}

Wengel, J ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Chem, Ctr Synthet Bioorgan Chem, DK-2100 Copenhagen, Denmark

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 07期

关键词：

D O I：

10.1039/a900458k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to investigate the structural basis of the unique hybridization properties of LNA (Locked Nucleic Acid), an abasic LNA monomer (a 1-deoxy-2-O,4-C-methylene-D-ribofuranose derivative) was synthesized and evaluated with respect to influence on duplex stability, showing that effects mediated via the nucleobase are pivotal for the properties of LNA.

引用

页码：657 / 658

页数：2

共 14 条

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