A Korean population study of the nine STR loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818

被引：37

作者：

Han, GR ^{[1
]}

Lee, YW ^{[1
]}

Lee, HL ^{[1
]}

Kim, SM ^{[1
]}

Ku, TW ^{[1
]}

Kang, IH ^{[1
]}

Lee, HS ^{[1
]}

Hwang, JJ ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Dept Legal Med, Seongbuk Gu, Seoul 136705, South Korea

来源：

INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 2000年 / 114卷 / 1-2期

关键词：

STR; allele frequency; Korea;

D O I：

10.1007/s004140000137

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

DNA typing was performed on 379 randomly selected unrelated Koreans using the nine short tandem repeat loci FGA, VWA, D3S1358 D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818 present in the AmpFlSTR Profiler Plus PCR amplification kit. Allele frequencies, heterozygosity, power of discrimination, mean exclusion chance, and polymorphism information content of each locus were calculated by statistical analysis. All nine loci were in Hardy-Weinberg equilibrium. The combined discrimination index and the combined mean exclusion chance in Koreans was 2.31 x 10(-12) and 0.99983, respectively. By evaluation of 297 children from 128 families, 2 mutations were found at the FGA locus and 1 each at the D18S51 and D13S317 loci. This study demonstrates that this multiplex system is a useful and convenient tool for forensic identification and parentage testing in Korea.

引用

页码：41 / 44

页数：4

共 10 条

[1]

ALFORD RL, 1994, AM J HUM GENET, V55, P190

[2]

BOTSTEIN D, 1980, AM J HUM GENET, V32, P314

[3] AUTOMATED SHORT TANDEM REPEAT (STR) ANALYSIS IN FORENSIC CASEWORK - A STRATEGY FOR THE FUTURE [J].

GILL, P ;

KIMPTON, CP ;

URQUHART, A ;

OLDROYD, N ;

MILLICAN, ES ;

WATSON, SK ;

DOWNES, TJ .

ELECTROPHORESIS, 1995, 16 (09) :1543-1552

[4] IDENTIFICATION OF THE REMAINS OF THE ROMANOV FAMILY BY DNA ANALYSIS [J].

GILL, P ;

IVANOV, PL ;

KIMPTON, C ;

PIERCY, R ;

BENSON, N ;

TULLY, G ;

EVETT, I ;

HAGELBERG, E ;

SULLIVAN, K .

NATURE GENETICS, 1994, 6 (02) :130-135

[5] PERFORMING THE EXACT TEST OF HARDY-WEINBERG PROPORTION FOR MULTIPLE ALLELES [J].

GUO, SW ;

THOMPSON, EA .

BIOMETRICS, 1992, 48 (02) :361-372

[6]

HAMMOND HA, 1994, AM J HUM GENET, V55, P175

[7] BLOOD SAMPLES - PROBABILITY OF DISCRIMINATION [J].

JONES, DA .

JOURNAL OF THE FORENSIC SCIENCE SOCIETY, 1972, 12 (02) :355-&

[8]

Kruger J, 1968, Dtsch Z Gesamte Gerichtl Med, V64, P127, DOI 10.1007/BF00586813

[9] Genotyping of forensic short tandem repeat (STR) systems based on sizing precision in a capillary electrophoresis instrument [J].

Lazaruk, K ;

Walsh, PS ;

Oaks, F ;

Gilbert, D ;

Rosenblum, BB ;

Menchen, S ;

Scheibler, D ;

Wenz, HM ;

Holt, C ;

Wallin, J .

ELECTROPHORESIS, 1998, 19 (01) :86-93

[10]

NEI M, 1974, GENETICS, V76, P379

← 1 →