ATP synthase: Motoring to the finish line

被引:34
作者
Senior, Alan E. [1 ]
机构
[1] Univ Rochester, Ctr Med, Dept Biochem & Biophys, Rochester, NY 14642 USA
关键词
D O I
10.1016/j.cell.2007.07.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protonmotive force produced by the electron transport chain is harnessed by the rotary molecular nanomotor ATP synthase to generate ATP. In this issue of Cell, Adachi et al. (2007), in a dazzling display of technical sophistication, now disentangle the coupling between the mechanical force generated by rotation of the ATP synthase subunits and the chemical reactions that occur simultaneously at the enzyme's three catalytic sites.
引用
收藏
页码:220 / 221
页数:2
相关论文
共 8 条
[1]   STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF F1-ATPASE FROM BOVINE HEART-MITOCHONDRIA [J].
ABRAHAMS, JP ;
LESLIE, AGW ;
LUTTER, R ;
WALKER, JE .
NATURE, 1994, 370 (6491) :621-628
[2]  
ADACHI K, 2007, CELL
[3]   Structure of bovine mitochondrial Fl-ATPase with nucleotide bound to all three catalytic sites: Implications for the mechanism of rotary catalysis [J].
Menz, RI ;
Walker, JE ;
Leslie, AGW .
CELL, 2001, 106 (03) :331-341
[4]   Direct observation of the rotation of F-1-ATPase [J].
Noji, H ;
Yasuda, R ;
Yoshida, M ;
Kinosita, K .
NATURE, 1997, 386 (6622) :299-302
[5]   The α3(βMet222Ser/Tyr345Trp)3γ subcomplex of the TF1-ATPase does not hydolyze ATP at a significant rate until the substrate binds to the catalytic site of the lowest affinity [J].
Ren, Huimiao ;
Bandyopadhyay, Sanjay ;
Allison, William S. .
BIOCHEMISTRY, 2006, 45 (19) :6222-6230
[6]   ATP synthase: what we know about ATP hydrolysis and what we do not know about ATP synthesis [J].
Weber, J ;
Senior, AE .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2000, 1458 (2-3) :300-309
[7]   ATP synthesis driven by proton transport in F1F0-ATP synthase [J].
Weber, J ;
Senior, AE .
FEBS LETTERS, 2003, 545 (01) :61-70
[8]   ATP synthase: Subunit-subunit interactions in the stator stalk [J].
Weber, Joachim .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2006, 1757 (9-10) :1162-1170