Composition and gene expression of the cag pathogenicity island in Helicobacter pylori strains isolated from gastric carcinoma and gastritis patients in Costa Rica

被引：51

作者：

Occhialini, A

Marais, A

Urdaci, M

Sierra, R

Muñoz, N

Covacci, A

Mégraud, F

机构：

[1] Hop Pellegrin, Bacteriol Lab, F-33076 Bordeaux, France

[2] Univ Bordeaux 2, Bacteriol Lab, F-33076 Bordeaux, France

[3] Ecole Natl Ingenieurs Travaux Agr, Microbiol Lab, F-33170 Gradignan, France

[4] Ctr Int Rech Canc, F-69372 Lyon, France

[5] Univ Costa Rica, San Jose, Costa Rica

[6] IRIS, I-53100 Siena, Italy

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 03期

关键词：

D O I：

10.1128/IAI.69.3.1902-1908.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The composition and in vitro expression of the cag pathogenicity island genes in a group of Helicobacter pylori strains obtained from patients suffering from chronic gastritis-associated dyspepsia (n = 26) or gastric carcinoma (n = 17) were analyzed. No significant difference in the distribution of the 10 studied regions was found between the cases and the controls, Nine strains did not harbor any of the selected regions: eight (30.8%) isolated from patients,vith gastritis only and one (5.9%) from a patient with gastric carcinoma. No association was found between the number of repeated sequences at the 3' end of the cagA gene or the presence of tyrosine phosphorylation motifs and the clinical origin of the strains. The virB10 homolog gene was the sole gene studied to be significantly expressed more often in cancer strains than in gastritis strains (P = 0.03).

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页码：1902 / 1908

页数：7

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