共 31 条
Synthesis of phosphino oxazoline ligand libraries from amino acid and phosphino carboxylate building blocks
被引:72
作者:
Gilbertson, SR
[1
]
Chang, CWT
[1
]
机构:
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
关键词:
D O I:
10.1021/jo981420y
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
A modular route to new phosphine-oxazoline ligands is reported. The ability of these ligands to asymmetrically catalyze the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate was investigated. The best of these Ligands gave a palladium complex which catalyzed the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate in a 99% yield and in 98% enantiomeric excess (Table 3, entry 11).
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页码:8424 / 8431
页数:8
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