Synthesis of phosphino oxazoline ligand libraries from amino acid and phosphino carboxylate building blocks

被引:72
作者
Gilbertson, SR [1 ]
Chang, CWT [1 ]
机构
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
关键词
D O I
10.1021/jo981420y
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A modular route to new phosphine-oxazoline ligands is reported. The ability of these ligands to asymmetrically catalyze the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate was investigated. The best of these Ligands gave a palladium complex which catalyzed the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate in a 99% yield and in 98% enantiomeric excess (Table 3, entry 11).
引用
收藏
页码:8424 / 8431
页数:8
相关论文
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