Systemic aspects of allergic disease: the role of the bone marrow

被引：46

作者：

Cyr, MM ^{[1
]}

Denburg, JA ^{[1
]}

机构：

[1] McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(01)00286-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, there has been an increasing appreciation of the important contribution of bone-marrow-related, hemopoietic mechanisms to allergic diseases. Eosinophil/basophil-progenitor levels fluctuate in the peripheral blood during allergen exposure and the cells home to peripheral tissue, where they differentiate. It is becoming apparent that several cytokines, particularly IL-5, have multiple effects on progenitors and allergic inflammation. Within the past few years, studies of the therapeutic implications of this bone marrow contribution to atopy have been initiated; the effects of corticosteroids, leukotriene-receptor blockers, antagonism of IL-5 and modulation of differentiation by retinoic acid on progenitors will be reviewed.

引用

页码：727 / 732

页数：6

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