Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample

Variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is a promising candidate for better understanding individual heterogeneity in subjective well-being or happiness, as measured by life satisfaction. This functional polymorphism has previously been associated with mental health and selective processing of positive and negative emotional stimuli. A case-control association study on a representative sample of Americans (N=2574) finds that individuals with the transcriptionally more efficient version of the serotonin transporter gene, report significantly higher levels of life satisfaction (P=0.01). This new finding may help explain the important genetic component of the individual baseline levels of happiness. Journal of Human Genetics (2011) 56, 456-459; doi:10.1038/jhg.2011.39; published online 12 May 2011