Functional polymorphism (5-HTTLPR) in the serotonin transporter gene is associated with subjective well-being: evidence from a US nationally representative sample

被引：65

作者：

De Neve, Jan-Emmanuel ^{[1
]}

机构：

[1] Univ London London Sch Econ & Polit Sci, Dept Govt, London WC2A 2AE, England

来源：

JOURNAL OF HUMAN GENETICS | 2011年 / 56卷 / 06期

关键词：

5-HTTLPR; happiness; life satisfaction; population genetics; serotonin transporter; subjective well-being; PROMOTER POLYMORPHISM; ANXIETY; TRAITS; DEPRESSION; ACTIVATION; ATTENTION; GENOTYPE;

D O I：

10.1038/jhg.2011.39

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is a promising candidate for better understanding individual heterogeneity in subjective well-being or happiness, as measured by life satisfaction. This functional polymorphism has previously been associated with mental health and selective processing of positive and negative emotional stimuli. A case-control association study on a representative sample of Americans (N=2574) finds that individuals with the transcriptionally more efficient version of the serotonin transporter gene, report significantly higher levels of life satisfaction (P=0.01). This new finding may help explain the important genetic component of the individual baseline levels of happiness. Journal of Human Genetics (2011) 56, 456-459; doi:10.1038/jhg.2011.39; published online 12 May 2011

引用

页码：456 / 459

页数：4

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