Endogenous retroviral sequences in the pathogenesis of systemic autoimmune disease

被引：6

作者：

Walchner, M

LeibMosch, C

Messer, G

Germaier, H

Plewig, G

Kind, P

机构：

[1] UNIV HEIDELBERG, KLINIKUM MANNHEIM, MED CLIN 3, HEIDELBERG, GERMANY

[2] GSF MUNICH, NATL RES CTR ENVIRONM & HLTH, INST MOL VIROL, NEUHERBERG, GERMANY

来源：

ARCHIVES OF DERMATOLOGY | 1997年 / 133卷 / 06期

关键词：

D O I：

10.1001/archderm.133.6.767

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Objectives: To update information on endogenous retroviral, sequences and discuss their role in systemic autoimmune disease. Data Sources: Articles retrieved after MEDLINE search and personal communications and cooperation with the Institute of Virology. Data Synthesis: There are 2 modes of pathogenetic mechanisms through which endogenous retroviral sequences could cause systemic autoimmune disease: expression of endogenous retroviral gene products sharing antigenic determinants with cellular proteins; and activation or destruction of cellular genes as a consequence of insertional mutagenesis. Both mechanisms have been demonstrated in vitro and in vivo in animal models. Conclusion: Investigations on endogenous retroviral sequences in humans may offer new insights into the pathogenesis of autoimmune disease.

引用

页码：767 / 771

页数：5

共 69 条

[1]

AHMED SA, 1985, AM J PATHOL, V121, P531

[2] HUMAN T-CELL LYMPHOTROPIC VIRUS (HTLV)-RELATED ENDOGENOUS SEQUENCE, HRES-1, ENCODES A 28-KDA PROTEIN - A POSSIBLE AUTOANTIGEN FOR HTLV-I GAG-REACTIVE AUTOANTIBODIES [J].