Genome architecture and the role of transcription

被引：36

作者：

Papantonis, Argyris ^{[1
]}

Cook, Peter R. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GENE-EXPRESSION; CHROMATIN ORGANIZATION; ACTIVATION; RECEPTOR; LOCUS; CONFORMATION; INITIATION; MODEL;

D O I：

10.1016/j.ceb.2010.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During development or in response to environmental stimuli, eukaryotic genes change both their expression and position in 3D nuclear space. Then, is a gene transcribed because of its position, or is position determined by transcription? Are genes stochastically or deterministically engaged in transcription cycles? Recent results confirm that RNA polymerases and their transcription factors play central roles in genome organization, and that stochastic events can give rise to apparently deterministic expression. As is so often the case in biology, structure both determines function and is influenced by it.

引用

页码：271 / 276

页数：6

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