PET imaging of nobiletin based on a practical total synthesis

被引：45

作者：

Asakawa, Tomohiro ^{[1
,2
]}

Hiza, Aiki ^{[1
,2
]}

Nakayama, Miho ^{[1
,2
]}

Inai, Makoto ^{[1
,2
]}

Oyama, Dai ^{[1
,2
]}

Koide, Hiroyuki ^{[1
,2
]}

Shimizu, Kosuke ^{[1
,2
]}

Wakimoto, Toshiyuki ^{[1
,2
]}

Harada, Norihiro ^{[3
]}

Tsukada, Hideo ^{[3
]}

Oku, Naoto ^{[1
,2
]}

Kan, Toshiyuki ^{[1
,2
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan

[2] Global COE Program, Shizuoka 4228526, Japan

[3] Hamamatsu Photon KK, Cent Res Lab, Hamakita Ku, Hamamatsu, Shizuoka 4348601, Japan

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 10期

关键词：

CONCISE SYNTHESIS; OXIDATIVE STRESS; FIBRIL FORMATION;

D O I：

10.1039/c0cc04936k

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of C-11 atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease.

引用

页码：2868 / 2870

页数：3

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