Genetic Associations of Variants in Genes Encoding HIV-Dependency Factors Required for HIV-1 Infection

被引：25

作者：

Chinn, Leslie W.

Tang, Minzhong

Kessing, Bailey D. ^{[7
]}

Lautenberger, James A.

Troyer, Jennifer L. ^{[7
]}

Malasky, Michael J. ^{[7
]}

McIntosh, Carl

Kirk, Gregory D. ^{[5
]}

Wolinsky, Steven M. ^{[4
]}

Buchbinder, Susan P. ^{[3
]}

Gomperts, Edward D. ^{[1
,2
]}

Goedert, James J. ^{[6
]}

O'Brien, Stephen J. ^{[8
]}

机构：

[1] Univ So Calif, Los Angeles, CA USA

[2] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[3] San Francisco Dept Publ Hlth, San Francisco, CA USA

[4] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[6] NCI, Rockville, MD USA

[7] Sci Applicat Int Corp, Frederick, MD USA

[8] NCI, Lab Genom Divers, Frederick, MD 21702 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 12期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; GENOME-WIDE ASSOCIATION; INTERACTION DATABASE; PROTEIN; AIDS; REPLICATION; COMPLEX; IDENTIFICATION; RESTRICTION; PROGRESSION;

D O I：

10.1086/657322

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. High-throughput genome-wide techniques have facilitated the identification of previously unknown host proteins involved in cellular human immunodeficiency virus (HIV) infection. Recently, 3 independent studies have used small interfering RNA technology to silence each gene in the human genome to determine the importance of each in HIV infection. Genes conferring a significant effect were termed HIV-dependency factors (HDFs). Methods. We assembled high-density panels of 6380 single-nucleotide polymorphisms (SNPs) in 278 HDF genes and tested for genotype associations with HIV infection and AIDS progression in 1633 individuals from clinical AIDS cohorts. Results. After statistical correction for multiple tests, significant associations with HIV acquisition were found for SNPs in 2 genes, NCOR2 and IDH1. Weaker associations with AIDS progression were revealed for SNPs within the TM9SF2 and EGFR genes. Conclusions. This study independently verifies the influence of NCOR2 and IDH1 on HIV transmission, and its findings suggest that variation in these genes affects susceptibility to HIV infection in exposed individuals.

引用

页码：1836 / 1845

页数：10

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