Ricin detection: Tracking active toxin

被引：89

作者：

Bozza, William P. ^{[1
]}

Tolleson, William H. ^{[2
]}

Rosado, Leslie A. Rivera ^{[1
,3
]}

Zhang, Baolin ^{[1
]}

机构：

[1] US FDA, Div Therapeut Prot, Off Biotechnol Prod, Ctr Drug Evaluat & Res, Bethesda, MD 20892 USA

[2] US FDA, Div Biochem Toxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

[3] US Publ Hlth Serv Commissioned Corps, Rockville, MD USA

来源：

BIOTECHNOLOGY ADVANCES | 2015年 / 33卷 / 01期

关键词：

Ricin; Bioterrorism; Detection methods; Plant toxins; RIBOSOME-INACTIVATING PROTEINS; RNA N-GLYCOSIDASE; PLASMON RESONANCE DETECTION; A-CHAIN; ENZYMATIC-ACTIVITY; LECTINS ABRIN; SENSITIVE METHOD; SHIGA TOXIN; B-CHAIN; ASSAY;

D O I：

10.1016/j.biotechadv.2014.11.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Ricin is a plant toxin with high bioterrorism potential due to its natural abundance and potency in inducing cell death. Early detection of the active toxin is essential for developing appropriate countermeasures. Here we review concepts for designing ricin detection methods, including mechanism of action of the toxin, advantages and disadvantages of current detection assays, and perspectives on the future development of rapid and reliable methods for detecting ricin in environmental samples. Published by Elsevier Inc.

引用

页码：117 / 123

页数：7

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