Subclinical cerebellar impairment in the common types of migraine:: A three dimensional analysis of reaching movements

被引：87

作者：

Sándor, PS

Mascia, A

Seidel, L

de Pasqua, V

Schoenen, J ^{[1
]}

机构：

[1] Univ Liege, Dept Neurol, CHR Citadelle, B-4000 Liege, Belgium

[2] Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland

[3] Univ Roma La Sapienza, Dept Neurol, Rome, Italy

[4] CHU Sart Tilman, Dept Biostat & Med Informat, B-4000 Liege, Belgium

来源：

ANNALS OF NEUROLOGY | 2001年 / 49卷 / 05期

关键词：

D O I：

10.1002/ana.1019

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia CACNA1A codes for the alpha (1), subunit of P/Q-Ca2+ channels and is highly expressed in the cerebellum. Using a pointing paradigm and infrared optoelectronic tracking system, we found subclinical hypermetria and other subtle cerebellar signs in the common forms of migraine. These were more pronounced in migraine with than without aura. Whether this reflects involvement of Ca2+ channel genes in the common types of migraine needs to be investigated by genetic analyses.

引用

页码：668 / 672

页数：5

共 21 条

[1] Impairment of neuromuscular transmission in a subgroup of migraine patients [J].