Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse

被引：51

作者：

Guttenplan, JB

Chen, M

Kosinska, W

Thompson, S

Zhao, ZL

Cohen, LA

机构：

[1] NYU, Dent Ctr, Div Basic Sci Biochem, New York, NY 10100 USA

[2] NYU, Med Ctr, Dept Environm Med, New York, NY 10016 USA

[3] Amer Hlth Fdn, Div Biostat, Valhalla, NY 10595 USA

[4] Amer Hlth Fdn, Div Nutr & Endocrinol, Valhalla, NY 10595 USA

来源：

CANCER LETTERS | 2001年 / 164卷 / 01期

关键词：

lacZ; mutagenesis; muta (TM) mouse; lycopene; prostate;

D O I：

10.1016/S0304-3835(00)00705-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Consumption of lycopene has been associated with reduced risk of prostate cancer. We have investigated the effects of lycopene. fed as a lycopene-rich tomato oleoresin (LTO) at two doses, on in vivo mutagenesis in prostate. colon, and lungs of lacZ mice. Both short-term benzo[a]pyrene (BaP)- induced and long-term spontaneous mutagenesis were monitored. Nonsignificant inhibition of spontaneous mutagenesis in prostate and colon was observed at the higher dose of LTO, and the observation of inhibition in colon was facilitated by an unusually high spontaneous mutagenesis rate. BaP-induced mutagensis was slightly inhibited by LTO in prostate. However, enhancement of BaP-induced-mutagenesis was observed in colon and Lung. These results indicate that any antimutagenic effects of LTO may be organospecific. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

共 28 条

[1] Effect of dietary lycopene on N-methylnitrosourea-induced mammary tumorigenesis [J].