Kainic acid-induced dorsal and ventral hippocampal seizures in rats

被引：39

作者：

Akaike, K

Tanaka, S

Tojo, H

Fukumoto, S

Imamura, S

Takigawa, M

机构：

[1] Kagoshima Univ, Fac Med, Dept Neuropsychiat, Kagoshima 8908520, Japan

[2] Kagoshima Univ, Fac Med, Dept Neurosurg, Kagoshima 8908520, Japan

来源：

BRAIN RESEARCH | 2001年 / 900卷 / 01期

关键词：

experimental epilepsy; kainic acid; hippocampus; limbic seizure;

D O I：

10.1016/S0006-8993(01)02252-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite reports of differing regional seizure susceptibility in the hippocampus. hippocampal initiation of limbic seizures has not been precisely localized. We compared seizures induced by kainic acid microinjection into the left dorsal and ventral hippocampus of rats. Discharges following ventral injections rapidly propagated to the left amygdala and sensorimotor cortex unlike seizures following dorsal injections. The ventral group showed various ictal behaviors including motor manifestations, while dorsally injected rats showed only immobilization. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：65 / 71

页数：7

共 16 条

[1]

Akaike Koichi, 1998, Epilepsia, V39, P34

[2]

CAVALHEIRO EA, 1982, ELECTROEN CLIN NEURO, V53, P581, DOI 10.1016/0013-4694(82)90134-1

[3] INTRA-DENTATE COLCHICINE RETARDS THE DEVELOPMENT OF AMYGDALA KINDLING [J].