Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

被引：35

作者：

Barreiro, Olga ^{[1
]}

Cibrian, Danay ^{[1
,2
,3
]}

Clemente, Cristina ^{[1
]}

Alvarez, David ^{[4
]}

Moreno, Vanessa ^{[1
]}

Valiente, Inigo ^{[5
]}

Bernad, Antonio ^{[5
]}

Vestweber, Dietmar ^{[6
]}

Arroyo, Alicia G. ^{[1
]}

Martin, Pilar ^{[1
]}

von Andrian, Ulrich H. ^{[4
,7
]}

Sanchez Madrid, Francisco ^{[1
,2
,3
]}

机构：

[1] Ctr Nacl Invest Cardiovasc, Dept Vasc Biol & Inflammat, Madrid, Spain

[2] Univ Autonoma Madrid, Hosp Princesa, Serv Inmunol, Madrid, Spain

[3] Univ Autonoma Madrid, Inst Invest Sanitaria Princesa, Madrid, Spain

[4] Harvard Med Sch, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

[5] Ctr Nacl Invest Cardiovasc, Dept Cardiovasc Dev & Repair, Madrid, Spain

[6] Max Planck Inst Mol Biomed, Munster, Germany

[7] Regon Inst MGH MIT & Harvard, Cambridge, MA USA

来源：

ELIFE | 2016年 / 5卷

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

DENDRITIC CELLS; IN-VIVO; BLOOD-VESSELS; KUPFFER CELLS; RNA-SEQ; EXPRESSION; MONOCYTES; ANTIGEN; STEM; LANGERHANS;

D O I：

10.7554/eLife.15251

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis.

引用

页数：33

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