Orchestration of Metabolism by Macrophages

被引：463

作者：

Biswas, Subhra K. ^{[1
]}

Mantovani, Alberto ^{[2
,3
]}

机构：

[1] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore

[2] Univ Milan, Ist Clin Humanitas IRCCS, I-20089 Milan, Italy

[3] Univ Milan, Dept Translat Med, I-20089 Milan, Italy

来源：

CELL METABOLISM | 2012年 / 15卷 / 04期

关键词：

TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE; POLARIZATION; INFLAMMATION; ACTIVATION; NEUTROPHILS; EXPRESSION; INNATE;

D O I：

10.1016/j.cmet.2011.11.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity, and inflammation. Macrophage products also impact metabolism, as illustrated by obesity-associated pathologies. Defining the mechanisms regulating macrophage metabolic activity and orchestration of metabolism by macrophages is crucial to pathology and therapeutic intervention.

引用

页码：432 / 437

页数：6

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