The-590C/T and-34C/T interleukin-4 promoter polymorphisms are not associated with atopic eczema in childhood

被引:34
作者
Elliott, K
Fitzpatrick, E
Hill, D
Brown, J
Adams, S
Chee, P
Stewart, G
Fulcher, D
Tang, MM
Kemp, A
King, E
Varigos, G
Bahlo, M
Forrest, S [1 ]
机构
[1] Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia
[2] Royal Childrens Hosp, Cooperat Res Ctr Discovery Genes Common Human Dis, Parkville, Vic 3052, Australia
[3] Royal Childrens Hosp, Allergy Ctr, Parkville, Vic 3052, Australia
[4] Westmead Hosp, Dept Clin Immunol & Allergy, Sydney, NSW, Australia
[5] Royal Childrens Hosp, Dept Dermatol, Parkville, Vic 3052, Australia
[6] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia
关键词
atopy; eczema; dermatitis; asthma; genetic; IL-4; promoter; polymorphism; association; linkage disequilibrium;
D O I
10.1067/mai.2001.117180
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Susceptibility to the development of asthma and other atopic diseases is known to have a genetic component. To date, several studies have linked chromosome 5q31 to asthma and atopy in human beings. This region harbors a cluster of cytokine and growth factor genes, IL-4 presenting as a prime atopy candidate gene, inasmuch as it plays a pivotal role in the atopy pathway. Our approach was to identify polymorphisms within the promoter regions of IL-4 and test their association with atopic eczema. Polymorphisms were typed in a cohort of 76 small nuclear families and 25 triads with childhood atopic eczema. The genotypes were used to test for linkage in the presence of association with atopic eczema. A new polymorphism, -34C/T, was identified and studied with a known polymorphism, -590C/T. On its own, each polymorphism showed no association with atopic eczema. The 2 polymorphisms were used to generate haplotypes, and a significant result was found for the -590C/-34C haplotype. However, after Bonferroni correction for multiple testing, the association became nonsignificant. Neither polymorphism predisposes to early-onset atopic eczema by itself, but suggestive linkage was found for the -590C/-34C haplotype in this study.
引用
收藏
页码:285 / 287
页数:3
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