An efficient synthesis of a Gal beta 1-3GalNAc-serine derivative using beta-galactosidase

被引：19

作者：

Suzuki, K

Fujimoto, H

Ito, Y

Sasaki, T

Ajisaka, K

机构：

[1] MEIJI MILK PROD CO LTD,MEIJI INST HLTH SCI,ODAWARA,KANAGAWA 250,JAPAN

[2] MEIJI MILK PROD CO LTD,CENT RES INST,ODAWARA,KANAGAWA 250,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(97)00019-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient route for the synthesis of Gal beta 1-3GalNAc alpha 1-O-Serine derivative was developed using a novel beta 1-3 galactosidase obtained from Bacillus circulans. By a transglycosylation reaction with pNP-beta-Gal 2 as a donor and GalNAc alpha-O-Z-Ser-OAll 4 as an acceptor, Gal beta 1-3GalNAc alpha-1-O-Z-Ser-OAll 5 was synthesized in 68% yield. (C) 1997, Elsevier Science Ltd.

引用

页码：1211 / 1214

页数：4

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