Toward a neurobiology of temporal cognition: Advances and challenges

被引:592
作者
Gibbon, J
Malapani, C
Dale, CL
Gallistel, CR
机构
[1] COLUMBIA UNIV, DEPT PSYCHOL, NEW YORK, NY 10027 USA
[2] HOP LA PITIE SALPETRIERE, INSERM, U289, F-75013 PARIS, FRANCE
[3] UNIV CALIF LOS ANGELES, DEPT PSYCHOL, LOS ANGELES, CA 90095 USA
关键词
D O I
10.1016/S0959-4388(97)80005-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A rich tradition of normative psychophysics has identified two ubiquitous properties of interval timing: the scalar property, a strong form of Weber's law, and ratio comparison mechanisms. Finding the neural substrate of these properties is a major challenge for neurobiology. Recently, advances have been made in our understanding of the brain structures important for timing, especially the basal ganglia and the cerebellum. Surgical intervention or diseases of the cerebellum generally result in increased variability in temporal processing, whereas both clock and memory effects are seen for neurotransmitter interventions, lesions and diseases of the basal ganglia. We propose that cerebellar dysfunction may induce deregulation of tonic thalamic tuning, which disrupts gating of the mnemonic temporal information generated in the basal ganglia through striato-thalamo-cortical loops.
引用
收藏
页码:170 / 184
页数:15
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