Microglial expression of the prion protein

被引：67

作者：

Brown, DR

Besinger, A

Herms, JW

Kretzschmar, HA

机构：

[1] MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England

[2] Univ Gottingen, Inst Neuropathol, D-37075 Gottingen, Germany

来源：

NEUROREPORT | 1998年 / 9卷 / 07期

关键词：

endotoxin; microglia; mouse; northern blot; PrP;

D O I：

10.1097/00001756-199805110-00032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE prion protein (PrPc) is a normal cellular protein expressed by neurones and astrocytes. An altered isoform, PrPSc is thought to transmit spongiform encephalopathies. Here we show that microglia also express PrPc. Sensitivity of microglia to activation is enhanced by increased expression of PrPc. Bacterial endotoxin increases superoxide production and inhibits profileration of microglia more effectively when microglia express PrPc. PrPc expression is therefore important for the normal function of microglia. (C) 1998 Rapid Science Ltd.

引用

页码：1425 / 1429

页数：5

共 24 条

[1] CDNA AND DEDUCED AMINO-ACID SEQUENCE OF MURINE CU-ZN SUPEROXIDE-DISMUTASE [J].