Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6-and IL-8-Expressing Tumors through Predominant Induction of CXCR1 by IL-6

被引：55

作者：

Eikawa, Shingo ^{[2
,3
]}

Ohue, Yoshihiro ^{[2
,3
]}

Kitaoka, Kenta ^{[2
]}

Aji, Toshiki ^{[2
]}

Uenaka, Akiko ^{[2
]}

Oka, Mikio ^{[3
]}

Nakayama, Eiichi ^{[1
,2
]}

机构：

[1] Kawasaki Univ Med Welf, Dept Hlth & Welf, Fac Hlth & Welf, Okayama 7010193, Japan

[2] Okayama Univ, Dept Immunol, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008530, Japan

[3] Kawasaki Med Sch, Dept Resp Med, Kurashiki, Okayama, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 11期

关键词：

IN-VITRO; INTERLEUKIN-6; EXPRESSION; CARCINOMA; GROWTH; TH17; DIFFERENTIATION; INHIBITION; TGF-BETA-1; PROGNOSIS;

D O I：

10.4049/jimmunol.1000225

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Analysis of cytokine and chemokine production by tumor cell lines including five lung cancers, a malignant mesothelioma, and a malignant melanoma recently established in our laboratory showed rather high production of IL-8 in all tumors and IL-6 in one lung cancer, the malignant mesothelioma, and the malignant melanoma. We investigated the migration of PBMCs to these tumor cells using Transwell plates and showed enrichment of Foxp3(+) CD4 regulatory T cells (Tregs) in migrated T cells to both IL-6- and IL-8-producing tumors. Marked induction of CXCR1 expression on Foxp3(+) CD4 Tregs by IL-6 followed by IL-8-mediated migration appeared to be responsible for enriched migration. Frequent production of IL-8 by the tumors and Treg migration to those tumors through induction of IL-8R expression by IL-6 is one of the mechanisms for tumor escape. The Journal of Immunology, 2010, 185: 6734-6740.

引用

页码：6734 / 6740

页数：7

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