Transduction of receptor signals by β-arrestins

被引:1363
作者
Leftowitz, RJ [1 ]
Shenoy, SK
机构
[1] Howard Hughes Med Inst, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Durham, NC 27710 USA
关键词
D O I
10.1126/science.1109237
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The transmission of extracellular signals to the interior of the cell is a function of plasma membrane receptors, of which the seven transmembrane receptor family is by far the largest and most versatile. Classically, these receptors stimulate heterotrimeric G proteins, which control rates of generation of diffusible second messengers and entry of ions at the plasma membrane. Recent evidence, however, indicates another previously unappreciated strategy used by the receptors to regulate intracellutar signaling pathways. They direct the recruitment, activation, and scaffolding of cytoplasmic signaling complexes via two multifunctional adaptor and transducer molecules, beta-arrestins 1 and 2. This mechanism regulates aspects of cell motility, chemotaxis, apoptosis, and likely other cellular functions through a rapidly expanding list of signaling pathways.
引用
收藏
页码:512 / 517
页数:6
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