Stem Leydig Cells: From Fetal to Aged Animals

被引：71

作者：

Chen, Haolin ^{[1
]}

Stanley, Erin ^{[1
]}

Jin, Shiying ^{[1
]}

Zirkin, Barry R. ^{[1
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Div Reprod Biol, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA

来源：

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS | 2010年 / 90卷 / 04期

关键词：

stem cell; Leydig cell; aging; ETHYLENE DIMETHANE SULFONATE; ANTI-MULLERIAN HORMONE; LUTEINIZING-HORMONE; ADULT-RAT; TESTOSTERONE PRODUCTION; BONE-MARROW; SELECTIVE DESTRUCTION; PROGENITOR CELLS; NEONATAL-HYPOTHYROIDISM; TESTICULAR MACROPHAGES;

D O I：

10.1002/bdrc.20192

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Leydig cells are the testosterone-producing cells of the testis. The adult Leydig cell (ALC) population ultimately develops from undifferentiated mesenchymal-like stem cells present in the interstitial compartment of the neonatal testis. Distinct stages of ALC development have been identified and characterized. These include stem Leydig cells (SLCs), progenitor Leydig cells, immature Leydig cells, and ALCs. This review describes our current understanding of the SLCs in the fetal, prenatal, peripubertal, adult, and aged rat testis, as well as recent studies of the differentiation of steroidogenic cells from the stem cells of other organs. Birth Defects Research (Part C) 90: 272-283, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：272 / 283

页数：12

共 111 条

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