The role of Th17 cytokines in primary mucosal immunity

被引：169

作者：

Kolls, Jay K. ^{[1
]}

Khader, Shabaana A. ^{[2
]}

机构：

[1] LSU Hlth Sci Ctr, Dept Genet, New Orleans, LA 70112 USA

[2] Childrens Hosp Pittsburgh, Div Infect Dis, Pittsburgh, PA 15224 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 06期

关键词：

Th17; Infection; Mucosa; COLONY-STIMULATING FACTOR; HYPER-IGE SYNDROME; PNEUMOCYSTIS-CARINII INFECTION; AIRWAY EPITHELIAL-CELLS; ACUTE SIV INFECTION; CD4(+) T-CELLS; ROR-GAMMA-T; IL-17; RECEPTOR; HOST-DEFENSE; MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1016/j.cytogfr.2010.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The T helper type 17 (Th17) lineage of CD4(+) T-cells produce several effector molecules including IL-17A, IL-17F, IL-21, and IL-22. In addition to CD4(+), alpha beta T-cells, these cytokines can be produced by natural killer and gamma delta T-cells. These effector cytokines can be produced rapidly upon infection at mucosal sites and evidence to date strongly implicates that this arm of the immune system plays a critical role in mucosal immunity to many extracellular pathogens. Moreover these cytokines can also coordinate adaptive immunity to some intracellular pathogens. In this review, we will highlight recent progress in our understanding of these cytokines, and mechanisms of their effector function in the mucosa. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：443 / 448

页数：6

共 91 条

[1]

IL-22: A critical mediator in mucosal host defense [J].

Aujla, S. J. ;

Kolls, J. K. .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2009, 87 (05) :451-454

[2]

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[3]

IL-17/Th17 Promotes Type 1 T Cell Immunity against Pulmonary Intracellular Bacterial Infection through Modulating Dendritic Cell Function [J].

Bai, Hong ;

Cheng, Jianjun ;

Gao, Xiaoling ;

Joyee, Antony George ;

Fan, Yijun ;

Wang, Shuhe ;

Jiao, Lei ;

Yao, Zhi ;

Yang, Xi .

JOURNAL OF IMMUNOLOGY, 2009, 183 (09) :5886-5895

[4]

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells [J].

Batten, Marcel ;

Li, Ji ;

Yi, Sothy ;

Kljavin, Noelyn M. ;

Danilenko, Dimitry M. ;

Lucas, Sophie ;

Lee, James ;

de Sauvage, Frederic J. ;

Ghilardi, Nico .

NATURE IMMUNOLOGY, 2006, 7 (09) :929-936

[5]

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling [J].

Boniface, Katia ;

Bak-Jensen, Kristian S. ;

Li, Ying ;

Blumenschein, Wendy M. ;

McGeachy, Mandy J. ;

McClanahan, Terrill K. ;

McKenzie, Brent S. ;

Kastelein, Robert A. ;

Cua, Daniel J. ;

Malefyt, Rene de Waal .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (03) :535-548

[6]

IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa [J].

Caruso, Roberta ;

Fina, Daniele ;

Paoluzi, Omero Alessandro ;

Blanco, Giovanna Del Vecchio ;

Stolfi, Carmine ;

Rizzo, Angelarnaria ;

Caprioli, Flavio ;

Sarra, Massimiliano ;

Andrei, Fabio ;

Fantini, Massimo Claudio ;

MacDonald, Thomas T. ;

Pallone, Francesco ;

Monteleone, Giovanni .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (02) :470-478

[7]

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity [J].

Cella, Marina ;

Fuchs, Anja ;

Vermi, William ;

Facchetti, Fabio ;

Otero, Karel ;

Lennerz, Jochen K. M. ;

Doherty, Jason M. ;

Mills, Jason C. ;

Colonna, Marco .

NATURE, 2009, 457 (7230) :722-725

[8]

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice [J].

Cho, John S. ;

Pietras, Eric M. ;

Garcia, Nairy C. ;

Ramos, Romela Irene ;

Farzam, David M. ;

Monroe, Holly R. ;

Magorien, Julie E. ;

Blauvelt, Andrew ;

Kolls, Jay K. ;

Cheung, Ambrose L. ;

Cheng, Genhong ;

Modlin, Robert L. ;

Miller, Lloyd S. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (05) :1762-1773

[9]

Expression and regulation of IL-22 in the IL-17-producing CD4+T lymphocytes [J].

Chung, Yeonseok ;

Yang, Xuexian ;

Chang, Seon Hee ;

Ma, Li ;

Tian, Qiang ;

Dong, Chen .

CELL RESEARCH, 2006, 16 (11) :902-907

[10]

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling [J].

Chung, Yeonseok ;

Chang, Seon Hee ;

Martinez, Gustavo J. ;

Yang, Xuexian O. ;

Nurieva, Roza ;

Kang, Hong Soon ;

Ma, Li ;

Watowich, Stephanie S. ;

Jetten, Anton M. ;

Tian, Qiang ;

Dong, Chen .

IMMUNITY, 2009, 30 (04) :576-587

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