Differential contribution of toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar typhimurium and Staphylococcus aureus in mice

被引：66

作者：

Lembo, A

Kalis, C

Kirschning, CJ

Mitolo, V

Jirillo, E

Wagner, H

Galanos, C

Freudenberg, MA

机构：

[1] Max Planck Inst Immunbiol, D-79108 Freiburg, Germany

[2] Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-8000 Munich, Germany

[3] Univ Bari, Fac Med, Policlin, Inst Anat, I-70124 Bari, Italy

[4] Univ Bari, Fac Med, Policlin, Dept Clin Med Immunol & Infect Dis, I-70124 Bari, Italy

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 10期

关键词：

D O I：

10.1128/IAI.71.10.6058-6062.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus.

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收藏

页码：6058 / 6062

页数：5

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