Antibody libraries in drug and target discovery

被引：24

作者：

Rader, C ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 01期

关键词：

D O I：

10.1016/S1359-6446(00)01595-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antibody libraries have come of age in the generation and evolution of monoclonal antibodies for therapeutic applications. Here, with an emphasis on cancer therapy, several examples are presented that illustrate the ability to design, engineer and select antibody libraries for different rationales in drug and target discovery.

引用

页码：36 / 43

页数：8

共 77 条

[1] Generating improved single-chain Fv molecules for tumor targeting [J].

Adams, GP ;

Schier, R .

JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 231 (1-2) :249-260

[2] RETRACTED: Directed evolution of new catalytic activity using the α/β-barrel scaffold (Retracted article. See vol 417, pg 468, 2002) [J].

Altamirano, MM ;

Blackburn, JM ;

Aguayo, C ;

Fersht, AR .

NATURE, 2000, 403 (6770) :617-622

[3]

Baca M, 1997, J BIOL CHEM, V272, P10678

[4] Selection and evolution of high-affinity human anti-viral antibodies [J].

Barbas, CF ;

Burton, DR .

TRENDS IN BIOTECHNOLOGY, 1996, 14 (07) :230-234

[5] SYNTHETIC HUMAN-ANTIBODIES [J].

BARBAS, CF .

NATURE MEDICINE, 1995, 1 (08) :837-839

[6] Immune versus natural selection: Antibody aldolases with enzymic rates but broader scope [J].

Barbas, CF ;

Heine, A ;

Zhong, GF ;

Hoffmann, T ;

Gramatikova, S ;

Bjornestedt, R ;

List, B ;

Anderson, J ;

Stura, EA ;

Wilson, IA ;

Lerner, RA .

SCIENCE, 1997, 278 (5346) :2085-2092

[7] ASSEMBLY OF COMBINATORIAL ANTIBODY LIBRARIES ON PHAGE SURFACES - THE GENE-III SITE [J].

BARBAS, CF ;

KANG, AS ;

LERNER, RA ;

BENKOVIC, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (18) :7978-7982

[8]

BARBOUR AK, 1994, ISS ENVIR SCI TECHN, V1, P1

[9] Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent [J].

Beiboer, SHW ;

Reurs, A ;

Roovers, RC ;

Arends, JW ;

Whitelegg, NR ;

Rees, AR ;

Hoogenboom, HR .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 296 (03) :833-849

[10] Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold [J].

Beste, G ;

Schmidt, FS ;

Stibora, T ;

Skerra, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :1898-1903

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