Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection

被引：246

作者：

Traub, LM ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 163卷 / 02期

关键词：

endocytosis; sorting; clathrin; cargo; AP-2;

D O I：

10.1083/jcb.200309175

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site.

引用

页码：203 / 208

页数：6

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