Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection

被引：246

作者：

Traub, LM ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 163卷 / 02期

关键词：

endocytosis; sorting; clathrin; cargo; AP-2;

D O I：

10.1083/jcb.200309175

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site.

引用

页码：203 / 208

页数：6

共 59 条

[11] Characterization of four mammalian numb protein isoforms - Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain [J].

Dho, SE ;

French, MB ;

Woods, SA ;

McGlade, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :33097-33104

[12] ENTH/ANTH domains expand to the Golgi [J].

Duncan, MC ;

Payne, GS .

TRENDS IN CELL BIOLOGY, 2003, 13 (05) :211-215

[13] Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1 [J].

Eden, ER ;

Patel, DD ;

Sun, XM ;

Burden, JJ ;

Themis, M ;

Edwards, M ;

Lee, P ;

Neuwirth, C ;

Naoumova, RP ;

Soutar, AK .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (11) :1695-1702

[14] Use of homozygosity mapping to identify a region on chromosome 1 bearing a defective gene that causes autosomal recessive homozygous hypercholesterolemia in two unrelated families [J].

Eden, ER ;

Naoumova, RP ;

Burden, JJ ;

McCarthy, MI ;

Soutar, AK .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (03) :653-660

[15] Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes [J].

Ford, MGJ ;

Pearse, BMF ;

Higgins, MK ;

Vallis, Y ;

Owen, DJ ;

Gibson, A ;

Hopkins, CR ;

Evans, PR ;

McMahon, HT .

SCIENCE, 2001, 291 (5506) :1051-1055

[16] Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding [J].

Gaidarov, I ;

Krupnick, JG ;

Falck, JR ;

Benovic, JL ;

Keen, JH .

EMBO JOURNAL, 1999, 18 (04) :871-881

[17] Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits [J].

Gaidarov, I ;

Keen, JH .

JOURNAL OF CELL BIOLOGY, 1999, 146 (04) :755-764

[18] Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein [J].

Garcia, CK ;

Wilund, K ;

Arca, M ;

Zuliani, G ;

Fellin, R ;

Maioli, M ;

Calandra, S ;

Bertolini, S ;

Cossu, F ;

Grishin, N ;

Barnes, R ;

Cohen, JC ;

Hobbs, HH .

SCIENCE, 2001, 292 (5520) :1394-1398

[19] ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2 [J].

He, GC ;

Gupta, S ;

Yi, M ;

Michaely, P ;

Hobbs, HH ;

Cohen, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (46) :44044-44049

[20] The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis [J].

Henry, KR ;

D'Hondt, K ;

Chang, JS ;

Nix, DA ;

Cope, MJTV ;

Chan, CSM ;

Drubin, DG ;

Lemmon, SK .

CURRENT BIOLOGY, 2003, 13 (17) :1564-1569

← 1 2 3 4 5 6 →