Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles

被引：246

作者：

Geng, Y ^{[1
]}

Discher, DE ^{[1
]}

机构：

[1] Univ Penn, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 37期

关键词：

D O I：

10.1021/ja053902e

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Spherical micelles and nanoparticles made with degradable polymers have been of great interest for therapeutic application, but degradation-induced changes in a spherical morphology can be subtle and mechanism/kinetics appears poorly understood. Here, we report the first preparation of giant and flexible worm micelles self-assembled from degradable copolymer poly(ethylene oxide)-block-polycaprolactone. Such worm micelles spontaneously shorten to generate spherical micelles, triggered by polycaprolactone hydrolysis, with distinct mechanism and kinetics from that which occurs in bulk material. Copyright © 2005 American Chemical Society.

引用

页码：12780 / 12781

页数：2

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