Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress

被引：105

作者：

Augoulea, A. ^{[1
,2
,3
]}

Alexandrou, A. ^{[4
]}

Creatsa, M. ^{[1
]}

Vrachnis, N. ^{[1
,2
,3
]}

Lambrinoudaki, I. ^{[1
]}

机构：

[1] Univ Athens, Aretaieion Hosp, Dept Obstet & Gynecol 2, GR-11526 Athens, Greece

[2] Univ Athens, Gynecol Unit, GR-11526 Athens, Greece

[3] Univ Athens, Evgenideio Hosp, Res Ctr, GR-11526 Athens, Greece

[4] Univ Athens, Laiko Hosp, Dept Surg 1, GR-11526 Athens, Greece

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2012年 / 286卷 / 01期

关键词：

Endometriosis; Oxidative stress; Genetic factors; Inflammation; ESTROGEN-RECEPTOR-ALPHA; ADVANCED-STAGE ENDOMETRIOSIS; PERITONEAL ENDOMETRIOSIS; POSSIBLE INVOLVEMENT; MONOZYGOTIC TWINS; OVARIAN-CANCER; WOMEN; POLYMORPHISMS; INFERTILITY; MARKERS;

D O I：

10.1007/s00404-012-2357-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. The etiology of this multifactorial disease is still unresolved and an increasing number of studies suggest that genetic, hormonal, environmental, immunological and oxidative factors may all play an important role in the pathogenesis of this disorder. In this literature review, inflammatory activity, oxidative stress as well as genetic abnormalities and mutations have been studied in an effort to identify factors predisposing to endometriosis.

引用

页码：99 / 103

页数：5

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