Intracellular calcium release from human platelets:: Different messengers for multiple stores

被引:52
作者
Jardin, Isaac [1 ]
Lopez, Jose J. [1 ]
Pariente, Jose A. [1 ]
Salido, Gines M. [1 ]
Rosado, Juan A. [1 ]
机构
[1] Univ Extremadura, Dept Physiol, Cell Physiol Res Grp, Caceres 10071, Spain
关键词
D O I
10.1016/j.tcm.2007.12.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Two separate Ca2+ stores have been reported in human platelets: the dense tubular system (DTS) and lysosome-like acidic organelles. Recent work has reported that Ca2+ release from the DTS is mediated by the generation of inositol 1,4,5-trisphosphate, whereas Ca2+ efflux from the acidic stores is mostly linked to nicotinic acid adenine dinucleotide phosphate. Platelet agonists release Ca2+ selectively from one or both stores, which provides additional insight into the complexity of Ca2+ signaling and the cellular functions activated. Here, we review the role, of multiple Ca2+ mobilizing messengers and Ca2+ stores in the activation of specific functions in platelets in response to different physiologic agonists.
引用
收藏
页码:57 / 61
页数:5
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