SCOP database in 2004: refinements integrate structure and sequence family data

被引：721

作者：

Andreeva, A

Howorth, D

Brenner, SE

Hubbard, TJP

Chothia, C

Murzin, AG

机构：

[1] MRC, Ctr Prot Engn, Cambridge CB2 2QH, England

[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[3] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

[4] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

关键词：

D O I：

10.1093/nar/gkh039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domains in SCOP are hierarchically classified into families, superfamilies, folds and classes. The continual accumulation of sequence and structural data allows more rigorous analysis and provides important information for understanding the protein world and its evolutionary repertoire. SCOP participates in a project that aims to rationalize and integrate the data on proteins held in several sequence and structure databases. As part of this project, starting with release 1.63, we have initiated a refinement of the SCOP classification, which introduces a number of changes mostly at the levels below superfamily. The pending SCOP reclassification will be carried out gradually through a number of future releases. In addition to the expanded set of static links to external resources, available at the level of domain entries, we have started modernization of the interface capabilities of SCOP allowing more dynamic links with other databases. SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop.

引用

页码：D226 / D229

页数：4

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