Therapeutic potential of Tregs to treat rheumatoid arthritis

被引：24

作者：

Wright, Graham P. ^{[1
]}

Stauss, Hans J. ^{[2
]}

Ehrenstein, Michael R. ^{[1
]}

机构：

[1] UCL, Ctr Rheumatol Res, London WC1E 6JF, England

[2] UCL, Royal Free Hosp, Dept Immunol, London NW3 2PF, England

来源：

SEMINARS IN IMMUNOLOGY | 2011年 / 23卷 / 03期

关键词：

REGULATORY T-CELLS; COLLAGEN-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; DENDRITIC CELLS; TGF-BETA; FOXP3; EXPRESSION; SELF-TOLERANCE; TRYPTOPHAN CATABOLISM; RECEPTOR INHIBITION; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.smim.2011.07.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there are a number of approaches currently being developed to utilise their potent immunosuppressive properties. Through genetic manipulation Tregs can be generated ex vivo or in vivo that target antigens present in the inflamed joint. Here we discuss these approaches, their refinement to restore tolerance in patients with rheumatoid arthritis, and strategies to prevent their conversion towards a Th17 phenotype. (C) 2011 Elsevier Ltd. All rights reserved.

引用

收藏

页码：195 / 201

页数：7

相关论文

共 78 条

[1]

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs [J].

Allan, SE ;

Passerini, L ;

Bacchetta, R ;

Crellin, N ;

Dai, MY ;

Orban, PC ;

Ziegler, SF ;

Roncarolo, MG ;

Levings, MK .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) :3276-3284

[2]

ARCE F, 2010, ARTHRITIS RHEUM

[3]

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt [J].

Ayyoub, Maha ;

Deknuydt, Florence ;

Raimbaud, Isabelle ;

Dousset, Christelle ;

Leveque, Lucie ;

Bioley, Gilles ;

Valmori, Danila .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (21) :8635-8640

[4]

TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes [J].

Belghith, M ;

Bluestone, JA ;

Barriot, S ;

Mégret, J ;

Bach, JF ;

Chatenoud, L .

NATURE MEDICINE, 2003, 9 (09) :1202-1208

[5]

IL-17-producing human peripheral regulatory T cells retain suppressive function [J].

Beriou, Gaelle ;

Costantino, Cristina M. ;

Ashley, Charles W. ;

Yang, Li ;

Kuchroo, Vijay K. ;

Baecher-Allan, Clare ;

Hafler, David A. .

BLOOD, 2009, 113 (18) :4240-4249

[6]

Collagen-induced arthritis [J].

Brand, David D. ;

Latham, Kary A. ;

Rosloniec, Edward F. .

NATURE PROTOCOLS, 2007, 2 (05) :1269-1275

[7]

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer [J].

Brusko, Todd M. ;

Koya, Richard C. ;

Zhu, Shirley ;

Lee, Michael R. ;

Putnam, Amy L. ;

McClymont, Stephanie A. ;

Nishimura, Michael I. ;

Han, Shuhong ;

Chang, Lung-Ji ;

Atkinson, Mark A. ;

Ribas, Antoni ;

Bluestone, Jeffrey A. .

PLOS ONE, 2010, 5 (07) :1-8

[8]

Chatenoud L, 1997, J IMMUNOL, V158, P2947

[9]

HUMAN INVIVO ANTIGENIC MODULATION INDUCED BY THE ANTI-T-CELL OKT3 MONOCLONAL-ANTIBODY [J].

CHATENOUD, L ;

BAUDRIHAYE, MF ;

KREIS, H ;

GOLDSTEIN, G ;

SCHINDLER, J ;

BACH, JF .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1982, 12 (11) :979-982

[10]

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease [J].

Chen, Xiao ;

Das, Rupali ;

Komorowski, Richard ;

Beres, Amy ;

Hessner, Martin J. ;

Mihara, Masahiko ;

Drobyski, William R. .

BLOOD, 2009, 114 (04) :891-900

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