The tale of RNA G-quadruplex

被引：136

作者：

Agarwala, Prachi ^{[1
,2
]}

Pandey, Satyaprakash ^{[1
,2
]}

Maiti, Souvik ^{[1
,2
,3
]}

机构：

[1] CSIR Inst Genom & Integrat Biol, Prote & Struct Biol Unit, Delhi 110007, India

[2] Anusandhan Bhawan, Acad Sci & Innovat Res AcSIR, New Delhi 110001, India

[3] CSIR Natl Chem Lab, Pune 411008, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 20期

关键词：

MENTAL-RETARDATION PROTEIN; REPEAT-CONTAINING RNA; HUMAN TELOMERIC RNA; PRE-MESSENGER-RNA; DNA G-QUADRUPLEX; ESTROGEN-RECEPTOR-ALPHA; STABLE G-QUADRUPLEX; YEAST GENE-PRODUCT; OPEN READING FRAME; G-RICH SEQUENCES;

D O I：

10.1039/c4ob02681k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

G-quadruplexes are non-canonical secondary structures found in guanine rich regions of DNA and RNA. Reports have indicated the wide occurrence of RNA G-quadruplexes across the transcriptome in various regions of mRNAs and non-coding RNAs. RNA G-quadruplexes have been implicated in playing an important role in translational regulation, mRNA processing events and maintenance of chromosomal end integrity. In this review, we summarize the structural and functional aspects of RNA G-quadruplexes with emphasis on recent progress to understand the protein/trans factors binding these motifs. With the revelation of the importance of these secondary structures as regulatory modules in biology, we have also evaluated the various advancements towards targeting these structures and the challenges associated with them. Apart from this, numerous potential applications of this secondary motif have also been discussed.

引用

页码：5570 / 5585

页数：16

共 197 条

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