Hypoglycemic effect of Acosmium panamense bark on streptozotocin diabetic rats

被引：27

作者：

Andrade-Cetto, A

Wiedenfeld, H

机构：

[1] Univ Nacl Autonoma Mexico, Dept Biol Celular, Fac Ciencias, Sch Sci Mexico, Mexico City 04510, DF, Mexico

[2] Univ Bonn, Inst Pharmaceut, D-53121 Bonn, Germany

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 90卷 / 2-3期

关键词：

Acosmium panamense; hypoglycemic effect; streptozotocin-induced diabetes;

D O I：

10.1016/j.jep.2003.09.049

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hypoglycemic effects of water and butanolic extracts prepared from the bark of Acosmium panamense (Fabaceae) were studied in diabetic rats (streptozotocin (STZ)-induced). Oral application of water extracts at doses of 20 and 200 mg/kg and of butanol extracts at doses of 20 and 100 mg/kg significantly lowered the plasma glucose levels in diabetic rats within 3 h. Glibenclamide was used as reference and showed similar hypoglycemic effect like the extracts. Three structurally new compounds were isolated from the plant and shown to be the main constituents in both extracts. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：217 / 220

页数：4

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