Pregnane glycoside multidrug-resistance modulators from Cynanchum wilfordii

被引：44

作者：

Hwang, BY

Kim, SE

Kim, YH

Kim, HS

Hong, YS

Ro, JS

Lee, KS

Lee, JJ

机构：

[1] Korea Res Inst Biosci & Biotechnol, Natl Prod Biosynth Res Unit, Taejon 305600, South Korea

[2] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 04期

关键词：

D O I：

10.1021/np980479x

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-beta-D-cymaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 mu M, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.

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页码：640 / 643

页数：4

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