A population-based description of glioblastoma multiforme in Los Angeles County, 1974-1999

被引:132
作者
Chakrabarti, I
Cockburn, M
Cozen, W
Wang, YP
Preston-Martin, S
机构
[1] Univ So Calif, Keck Sch Med, Dept Neurosurg, Los Angeles, CA 90032 USA
[2] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90032 USA
[3] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90032 USA
关键词
glioblastoma multiforme; epidemiology; incidence; race; outcomes;
D O I
10.1002/cncr.21539
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. There have been reports that the incidence rates of brain tumors have increased over the past few decades, but most have considered all brain tumors together. The authors analyzed the pattern of glioblastoma multiforme (GBM) occurrence in Los Angeles County, California to shed light on the incidence and descriptive epidemiology of this type of brain tumor. METHODS. Data were obtained from the Los Angeles County Cancer Surveillance Program. Incidence rates were analyzed by gender, race, age at diagnosis, period of diagnosis (1974-1981, 1982-1988, or 1989-1999), and socioeconomic status (SES). In addition, data were stratified according to anatomic subsite. A multivariate model describing changes in rates by each of these variables was constructed. RESULTS. Age-specific incidence rates (ASIR) rose sharply after age 30 years. The peak ASIR was at age 70-74 years in males and at age 75-79 years in females. The age-adjusted incidence rate (AAIR) of GBM increased from 1974 to 1999 by an estimated 2.4% per year among males and 2.8% per year among females. Overall, males had a 60% increased risk of brain tumors compared with females. Males had a higher incidence of GFM compared with females at each anatomic subsite except the posterior fossa. The largest male:female ratio occurred in the occipital lobes. Non-Latino whites had the highest incidence rates (2.5 per 100,000) followed by Latino whites (1.8 per 100,000), and blacks (1.5 per 100,000). After 1989, compared with the period before magnetic resonance imaging (MRI) was available, there was an increase in GBM incidence rates among those with of higher SES that was most pronounced in females. The incidence of GEM was highest for frontal lobe tumors and for tumors that involved two or more lobes (overlapping tumors), followed by tumors in the temporal and parietal lobes. In the multivariate analysis, year of diagnosis, SES, gender, race (Latino but not black), site, and age at diagnosis all were important predictors of incidence rate. CONCLUSIONS. GBM incidence increased in Los Angeles County over the last 30 years and especially after 1989, suggesting that the introduction of MRI may have contributed to the increase. Individuals older than age 65 years experienced the greatest increase in incidence over time. Older age, male gender, higher SES, and non-Latino white race increased the risk of GBM. Previously unreported incidence rates for GBM among Latino whites were significantly lower than among non-Latino whites but were intermediate between non-Latino whites and blacks.
引用
收藏
页码:2798 / 2806
页数:9
相关论文
共 34 条
[1]   Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997 [J].
Barnholtz-Sloan, JS ;
Sloan, AE ;
Schwartz, AG .
JOURNAL OF NEUROSURGERY, 2003, 99 (03) :458-466
[2]  
Breslow NE, 1980, IARC SCI PUBL, V1
[3]  
BUELL P, 1960, J CHRON DIS, V12, P600
[4]   Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973-1991 [J].
Davis, FG ;
Freels, S ;
Grutsch, J ;
Barlas, S ;
Brem, S .
JOURNAL OF NEUROSURGERY, 1998, 88 (01) :1-10
[5]   INCREASING INCIDENCE OF PRIMARY MALIGNANT BRAIN-TUMORS - INFLUENCE OF DIAGNOSTIC METHODS [J].
DESMEULES, M ;
MIKKELSEN, T ;
MAO, Y .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (06) :442-445
[6]   Sex differences in length of survival with malignant astrocytoma, but not with glioblastoma [J].
Diete, S ;
Treuheit, T ;
Dietzmann, K ;
Schmidt, U ;
Wallesch, CW .
JOURNAL OF NEURO-ONCOLOGY, 2001, 53 (01) :47-49
[7]  
Fleury A, 1997, CANCER, V79, P1195, DOI 10.1002/(SICI)1097-0142(19970315)79:6<1195::AID-CNCR19>3.0.CO
[8]  
2-V
[9]   INCREASING ANNUAL INCIDENCE OF PRIMARY MALIGNANT BRAIN-TUMORS IN THE ELDERLY [J].
GREIG, NH ;
RIES, LG ;
YANCIK, R ;
RAPOPORT, SI .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (20) :1621-1624
[10]   INFLUENCE OF EXTENT OF SURGERY AND TUMOR LOCATION ON TREATMENT OUTCOME OF PATIENTS WITH GLIOBLASTOMA-MULTIFORME TREATED WITH COMBINED-MODALITY APPROACH [J].
JEREMIC, B ;
GRUJICIC, D ;
ANTUNOVIC, V ;
DJURIC, L ;
STOJANOVIC, M ;
SHIBAMOTO, Y .
JOURNAL OF NEURO-ONCOLOGY, 1994, 21 (02) :177-185