Prion proteins meet protein quality control

被引：20

作者：

Dimcheff, DE ^{[1
]}

Portis, JL ^{[1
]}

Caughey, B ^{[1
]}

机构：

[1] NIAID, Rocky Mt Labs, Persistent Viral Dis Lab, Hamilton, MT 59840 USA

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0962-8924(03)00125-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent work on transmissible spongiform encephalopathies (TSEs) suggests a role for protein quality-control mechanisms in both prion protein aggregation and pathogenesis. Cytosolic accumulation of prion protein seems to be neurotoxic and might occur when proteasome function is compromised and quality control is overwhelmed. These findings are discussed in the light of other studies linking proteasome inhibition and neurodegeneration.

引用

页码：337 / 340

页数：4

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