Molecular pathways for cancer angioprevention

被引：43

作者：

Albini, Adriana

Noonan, Douglas M.

Ferrari, Nicoletta

机构：

[1] IRCCS Multimed, I-20138 Milan, Italy

[2] Univ Insubria, Varese, Italy

[3] Ist Nazl Ric Canc, I-16132 Genoa, Italy

来源：

CLINICAL CANCER RESEARCH | 2007年 / 13卷 / 15期

关键词：

D O I：

10.1158/1078-0432.CCR-07-0069

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

By analogy to the success of cardiovascular medicine in reducing mortality through preventive measures, cancer chemoprevention has the potential to significantly reduce incidence and mortality due to tumors. Angiogenesis is an event inhibited by most of the promising cancer chemoprevention compounds, a concept we termed "angioprevention." Here, we review the signaling pathways that are targeted by diverse angioprevention compounds in endothelial cells. We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice.

引用

收藏

页码：4320 / 4325

页数：6

相关论文

共 80 条

[1]

Insulin-like growth factor-I axis as a pathway for cancer chemoprevention [J].

Adhami, Vaqar Mustafa ;

Afaq, Farrukh ;

Mukhtar, Hasan .

CLINICAL CANCER RESEARCH, 2006, 12 (19) :5611-5614

[2]

Molecular targets for green tea in prostate cancer prevention [J].

Adhami, VM ;

Ahmad, N ;

Mukhtar, H .

JOURNAL OF NUTRITION, 2003, 133 (07) :2417S-2424S

[3]

Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol:: NF-κB and Akt as targets [J].

Albini, A ;

Dell'Eva, R ;

Vené, R ;

Ferrari, N ;

Buhler, DR ;

Noonan, DM ;

Fassina, G .

FASEB JOURNAL, 2005, 19 (14) :527-+

[4]

The tumour microenvironment as a target for chemoprevention [J].

Albini, Adriana ;

Sporn, Michael B. .

NATURE REVIEWS CANCER, 2007, 7 (02) :139-147

[5]

Celecoxib for the prevention of colorectal adenomatous polyps [J].

Arber, Nadir ;

Eagle, Craig J. ;

Spicak, Julius ;

Racz, Istvan ;

Dite, Petr ;

Hajer, Jan ;

Zavoral, Miroslav ;

Lechuga, Maria J. ;

Gerletti, Paola ;

Tang, Jie ;

Rosenstein, Rebecca B. ;

Macdonald, Katie ;

Bhadra, Pritha ;

Fowler, Robert ;

Wittes, Janet ;

Zauber, Ann G. ;

Solomon, Scott D. ;

Levin, Bernard .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :885-895

[6]

Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity [J].

Bagli, E ;

Stefaniotou, M ;

Morbidelli, L ;

Ziche, M ;

Psillas, K ;

Murphy, C ;

Fotsis, T .

CANCER RESEARCH, 2004, 64 (21) :7936-7946

[7]

A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells [J].

Basu, Gargi D. ;

Liang, Winnie S. ;

Stephan, Dietrich A. ;

Wegener, Lee T. ;

Conley, Christopher R. ;

Pockaj, Barbara A. ;

Mukherjee, Pinku .

BREAST CANCER RESEARCH, 2006, 8 (06)

[8]

Celecoxib for the prevention of sporadic colorectal adenomas [J].

Bertagnolli, Monica M. ;

Eagle, Craig J. ;

Zauber, Ann G. ;

Redston, Mark ;

Solomon, Scott D. ;

Kim, KyungMann ;

Tang, Jie ;

Rosenstein, Rebecca B. ;

Wittes, Janet ;

Corle, Donald ;

Hess, Timothy M. ;

Woloj, G. Mabel ;

Boisserie, Frederic ;

Anderson, William F. ;

Viner, Jaye L. ;

Bagheri, Donya ;

Burn, John ;

Chung, Daniel C. ;

Dewar, Thomas ;

Foley, T. Raymond ;

Hoffman, Neville ;

Macrae, Finlay ;

Pruitt, Ronald E. ;

Saltzman, John R. ;

Salzberg, Bruce ;

Sylwestrowicz, Thomas ;

Gordon, Gary B. ;

Hawk, Ernest T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :873-884

[9]

Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study [J].

Bettuzzi, S ;

Brausi, M ;

Rizzi, F ;

Castagnetti, G ;

Peracchia, G ;

Corti, A .

CANCER RESEARCH, 2006, 66 (02) :1234-1240

[10]

A functional role for hemostasis in early cancer development,. [J].

Boccaccio, C ;

Comoglio, PM .

CANCER RESEARCH, 2005, 65 (19) :8579-8582

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