5-HT3 receptor antagonists

被引：12

作者：

Silverstone, PH ^{[1
]}

Greenshaw, AJ ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT PSYCHIAT,NEUROCHEM RES UNIT,EDMONTON,AB T6G 2B7,CANADA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1517/13543776.6.5.471

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antagonists of the serotonin 5-HT3 receptor are clinically effective antinausea and anti-emetic drugs for the treatment of cancer patients undergoing chemotherapy and for patients undergoing procedures involving general anaesthesia. These compounds have also been evaluated for the treatment of irritable bowel syndrome, other pain-related disorders (including migraine) and a variety of central nervous system disorders (including anxiety, psychosis and the treatment of drug abuse). The status of research into potential clinical applications of these drugs is evaluated in this review. The evidence from preclinical and clinical studies is compared and avenues for future drug development using these compounds are discussed.

引用

页码：471 / 481

页数：11

共 82 条

[1] BLOCKADE OF ACQUISITION OF DRUG-CONDITIONED PLACE AVERSION BY 5HT3 ANTAGONISTS [J].

ACQUAS, E ;

CARBONI, E ;

GARAU, L ;

DICHIARA, G .

PSYCHOPHARMACOLOGY, 1990, 100 (04) :459-463

[2]

ALHAIDER AA, 1991, J NEUROSCI, V11, P1881

[3] 5HT(3) RECEPTOR ANTAGONISTS DO NOT BLOCK NICOTINE-INDUCED HYPERACTIVITY IN RATS [J].

ARNOLD, B ;

ALLISON, K ;

IVANOVA, S ;

PAETSCH, PR ;

PASLAWSKI, T ;

GREENSHAW, AJ .

PSYCHOPHARMACOLOGY, 1995, 119 (02) :213-221

[4] THE PHARMACOLOGY OF VA21B7 - AN ATYPICAL 5-HT3 RECEPTOR ANTAGONIST WITH ANXIOLYTIC-LIKE PROPERTIES IN ANIMAL-MODELS [J].

ARTAIZ, I ;

ROMERO, G ;

ZAZPE, A ;

MONGE, A ;

CALDERO, JM ;

ROCA, J ;

LASHERAS, B ;

DELRIO, J .

PSYCHOPHARMACOLOGY, 1995, 117 (02) :137-148

[5] SR-57227A - A POTENT AND SELECTIVE AGONIST AT CENTRAL AND PERIPHERAL 5-HT(3) RECEPTORS IN-VITRO AND IN-VIVO [J].

BACHY, A ;

HEAULME, M ;

GIUDICE, A ;

MICHAUD, JC ;

LEFEVRE, IA ;

SOUILHAC, J ;

MANARA, L ;

EMERIT, MB ;

GOZLAN, H ;

HAMON, M ;

KEANE, PE ;

SOUBRIE, P ;

LEFUR, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 237 (2-3) :299-309

[6] DIFFERENCES BETWEEN 5-HT3 RECEPTOR ANTAGONISTS IN MODULATION OF VISCERAL HYPERSENSITIVITY [J].

BANNER, SE ;

SANGER, GJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (02) :558-562

[7] 5-HT3 RECEPTORS MEDIATE INHIBITION OF ACETYLCHOLINE-RELEASE IN CORTICAL TISSUE [J].

BARNES, JM ;

BARNES, NM ;

COSTALL, B ;

NAYLOR, RJ ;

TYERS, MB .

NATURE, 1989, 338 (6218) :762-763

[8] SEROTONIN 5-HT3 ANTAGONISTS FAIL TO AFFECT ETHANOL SELF-ADMINISTRATION OF RATS [J].

BEARDSLEY, PM ;

LOPEZ, OT ;

GULLIKSON, G ;

FLYNN, D .

ALCOHOL, 1994, 11 (05) :389-395

[9] BEHAVIORAL-STUDIES ON WAY100289, A NOVEL 5-HT(3) RECEPTOR ANTAGONIST, IN 2 ANIMAL-MODELS OF ANXIETY [J].

BILL, DJ ;

FLETCHER, A ;

GLENN, BD ;

KNIGHT, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 218 (2-3) :327-334

[10] BRL-46470A - A HIGHLY POTENT, SELECTIVE AND LONG-ACTING 5-HT(3) RECEPTOR ANTAGONIST WITH ANXIOLYTIC-LIKE PROPERTIES [J].

BLACKBURN, TP ;

BAXTER, GS ;

KENNETT, GA ;

KING, FD ;

PIPER, DC ;

SANGER, GJ ;

THOMAS, DR ;

UPTON, N ;

WOOD, MD .

PSYCHOPHARMACOLOGY, 1993, 110 (03) :257-264

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