Effects of a plasmid-encoded qnrA1 determinant in Escherichia coli strains carrying chromosomal mutations in the acrAB efflux pump genes

被引：18

作者：

Jeong, Jin-Yong ^{[1
,2
,4
]}

Kim, Eun Sil ^{[1
,2
]}

Choi, Sang-Ho ^{[1
,2
]}

Kwon, Hyun-Hee ^{[1
,2
]}

Lee, Sang-Rok ^{[1
,2
]}

Lee, Sang-Oh ^{[1
,2
]}

Kim, Mi-Na ^{[3
]}

Woo, Jun Hee ^{[1
,2
]}

Kim, Yang Soo ^{[1
,2
]}

机构：

[1] Univ Ulsan, Coll Med, Div Infect Dis, Asan Med Ctr, Seoul 138736, South Korea

[2] Univ Ulsan, Ctr Antimicrobial Resistance & Microbial Genet, Seoul 138736, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Lab Med, Seoul 138736, South Korea

[4] Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul 138736, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2008年 / 60卷 / 01期

关键词：

plasmid-mediated quinolone resistance; qnrA1; AcrAB efflux pump;

D O I：

10.1016/j.diagmicrobio.2007.07.015

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The qnrA1 gene was cloned into a plasmid vector and transformed into Escherichia coli strains carrying chromosomal mutations in the acrAB drug efflux system. In acrAB-deleted strains, and in strains overexpressing acrAB, viable qnrA conferred higher MIC levels (at least a 32-fold increase) for fluoroquinolones than were observed in the parent strains. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：105 / 107

页数：3

共 13 条

[1]

*CLIN LAB STAND I, 2006, MTEH DIL ANT SUSC TE

[2] Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica [J].

Gay, K ;

Robicsek, A ;

Strahilevitz, J ;

Park, CH ;

Jacoby, G ;

Barrett, TJ ;

Medalla, F ;

Chiller, TM ;

Hooper, DC .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (03) :297-304

[3] Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneti 2b [J].

Hata, M ;

Suzuki, M ;

Matsumoto, M ;

Takahashi, M ;

Sato, K ;

Ibe, S ;

Sakae, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :801-803

[4] Emerging mechanisms of fluoroquinolone resistance [J].

Hooper, DC .

EMERGING INFECTIOUS DISEASES, 2001, 7 (02) :337-341

[5] qnrB, another plasmid-mediated gene for quinolone resistance [J].

Jacoby, GA ;

Walsh, KE ;

Mills, DM ;

Walker, VJ ;

Oh, H ;

Robicsek, A ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1178-1182

[6] Detection of qnr in clinical isolates of Escherichia coli from Korea [J].

Jeong, JY ;

Yoon, HJ ;

Kim, ES ;

Lee, Y ;

Choi, SH ;

Kim, NJ ;

Woo, JH ;

Kim, YS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (06) :2522-2524

[7] Interaction of plasmid and host quinolone resistance [J].

Martínez-Martínez, L ;

Pascual, A ;

García, I ;

Tran, J ;

Jacoby, GA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (04) :1037-1039

[8] AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants [J].

Okusu, H ;

Ma, D ;

Nikaido, H .

JOURNAL OF BACTERIOLOGY, 1996, 178 (01) :306-308

[9] The worldwide emergence of plasmid-mediated quinolone resistance [J].

Robicsek, Ari ;

Jacoby, George A. ;

Hooper, David C. .

LANCET INFECTIOUS DISEASES, 2006, 6 (10) :629-640

[10] Mechanism of plasmid-mediated quinolone resistance [J].

Tran, JH ;

Jacoby, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5638-5642

← 1 2 →