New methodologies for the synthesis of compound libraries

被引：133

作者：

Kobayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Tokyo Univ Sci, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 162, Japan

来源：

CHEMICAL SOCIETY REVIEWS | 1999年 / 28卷 / 01期

关键词：

D O I：

10.1039/a707429h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New methodologies for the synthesis of compound libraries are discussed. They are based on new carbon-carbon bond-forming reactions on the solid-phase (using polymer-supported silyl enol ethers), library preparation using polymer catalysts, and multi-component reactions in liquid phase. Development of new linker resins for efficient reactions on the solid-phase and a new method for the synthesis of monosaccharide libraries are also described.

引用

页码：1 / 15

页数：15

共 36 条

[1] Multiple-component condensation strategies for combinatorial library synthesis [J].

Armstrong, RW ;

Combs, AP ;

Tempest, PA ;

Brown, SD ;

Keating, TA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :123-131

[2]

DANISHEFSKY SJ, 1989, ACS SYM SER, V386, P176

[3]

HORTON D, 1989, ACS S SERIES, V386

[4] CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides [J].

Kawano, T ;

Cui, JQ ;

Koezuka, Y ;

Toura, I ;

Kaneko, Y ;

Motoki, K ;

Ueno, H ;

Nakagawa, R ;

Sato, H ;

Kondo, E ;

Koseki, H ;

Taniguchi, M .

SCIENCE, 1997, 278 (5343) :1626-1629

[5] TOTAL SYNTHESIS OF THE L-HEXOSES [J].

KO, SY ;

LEE, AWM ;

MASAMUNE, S ;

REED, LA ;

SHARPLESS, KB ;

WALKER, FJ .

TETRAHEDRON, 1990, 46 (01) :245-264

[6]

KOBAYASHI S, 1994, SYNLETT, P689

[7] Polymer scandium-catalyzed three-component reactions leading to diverse amino ketone, amino ester, and amino nitrile derivatives [J].

Kobayashi, S ;

Nagayama, S ;

Busujima, T .

TETRAHEDRON LETTERS, 1996, 37 (51) :9221-9224

[8] Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library [J].

Kobayashi, S ;

Hachiya, I ;

Suzuki, S ;

Moriwaki, M .

TETRAHEDRON LETTERS, 1996, 37 (16) :2809-2812

[9] Parallel synthesis using mannich-type three-component reactions and ''field synthesis'' for the construction of an amino alcohol library [J].

Kobayashi, S ;

Moriwaki, M ;

Akiyama, R ;

Suzuki, S ;

Hachiya, I .

TETRAHEDRON LETTERS, 1996, 37 (43) :7783-7786

[10] 5-(4'-chloromethylphenyl)pentylpolystyrene resin (CMPP resin). A new linker resin for solid-phase organic synthesis under Lewis acidic conditions [J].

Kobayashi, S ;

Moriwaki, M .

TETRAHEDRON LETTERS, 1997, 38 (24) :4251-4254

← 1 2 3 4 →