Mutations of the activation-associated phosphorylation sites at codons 308 and 473 of protein kinase B are absent in human melanoma

被引:14
作者
Waldmann, V [1 ]
Wacker, J [1 ]
Deichmann, M [1 ]
机构
[1] Heidelberg Univ, Dept Dermatol, D-69115 Heidelberg, Germany
关键词
oncogene; tumor suppressor gene; carcinogenesis;
D O I
10.1007/s004030100236
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
[No abstract available]
引用
收藏
页码:368 / 372
页数:5
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共 25 条
  • [1] Mechanism of activation of protein kinase B by insulin and IGF-1
    Alessi, DR
    Andjelkovic, M
    Caudwell, B
    Cron, P
    Morrice, N
    Cohen, P
    Hemmings, BA
    [J]. EMBO JOURNAL, 1996, 15 (23) : 6541 - 6551
  • [2] The Akt kinase:: Molecular determinants of oncogenicity
    Aoki, M
    Batista, O
    Bellacosa, A
    Tsichlis, P
    Vogt, PK
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) : 14950 - 14955
  • [3] Akt activation by growth factors is a multiple-step process: the role of the PH domain
    Bellacosa, A
    Chan, TO
    Ahmed, NN
    Datta, K
    Malstrom, S
    Stokoe, D
    McCormick, F
    Feng, JN
    Tsichlis, P
    [J]. ONCOGENE, 1998, 17 (03) : 313 - 325
  • [4] PROTEIN-KINASE-B (C-AKT) IN PHOSPHATIDYLINOSITOL-3-OH INASE SIGNAL-TRANSDUCTION
    BURGERING, BMT
    COFFER, PJ
    [J]. NATURE, 1995, 376 (6541) : 599 - 602
  • [5] AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
    Chan, TO
    Rittenhouse, SE
    Tsichlis, PN
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 : 965 - 1014
  • [6] Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
    Chang, HW
    Aoki, M
    Fruman, D
    Auger, KR
    Bellacosa, A
    Tsichlis, PN
    Cantley, LC
    Roberts, TM
    Vogt, PK
    [J]. SCIENCE, 1997, 276 (5320) : 1848 - 1850
  • [7] Davies MA, 1998, CANCER RES, V58, P5285
  • [8] Representative cDNA libraries and their utility in gene expression profiling
    Endege, WO
    Steinmann, KE
    Boardman, LA
    Thibodeau, SN
    Schlegel, R
    [J]. BIOTECHNIQUES, 1999, 26 (03) : 542 - +
  • [9] THE PROTEIN-KINASE ENCODED BY THE AKT PROTOONCOGENE IS A TARGET OF THE PDGF-ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE
    FRANKE, TF
    YANG, SI
    CHAN, TO
    DATTA, K
    KAZLAUSKAS, A
    MORRISON, DK
    KAPLAN, DR
    TSICHLIS, PN
    [J]. CELL, 1995, 81 (05) : 727 - 736
  • [10] Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
    Haas-Kogan, D
    Shalev, N
    Wong, M
    Mills, G
    Yount, G
    Stokoe, D
    [J]. CURRENT BIOLOGY, 1998, 8 (21) : 1195 - 1198