The "Complex-in-a-Complex" cations [(acac)2M⊂RU6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+:: A Trojan horse for cancer cells

被引：404

作者：

Therrien, Bruno ^{[1
]}

Suess-Fink, Georg ^{[1
]}

Govindaswamy, Padavattan ^{[1
]}

Renfrew, Anna K. ^{[2
]}

Dyson, Paul J. ^{[2
]}

机构：

[1] Univ Neuchatel, Inst Chim, CH-2009 Neuchatel, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 20期

关键词：

antitumor agents; arene ligands; bioinorganic chemistry; ruthenium; supramolecular chemistry;

D O I：

10.1002/anie.200800186

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The start of an odyssey? The cytotoxicities of the large cationic arene-ruthenium prismatic cage 16+, and its "complex-in-a-complex" derivatives [(acac)2M⊂1] 6+ (M = Pd, Pt; acac = acetylacetonate; see picture), are evaluated in comparison with free [M(acac)2]. The differences in cytotoxicity suggest that, like a "Trojan Horse", leaching of the guest from the cage once inside a cell accelerates and increases the cytotoxic effect. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3773 / 3776

页数：4

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